Stress-Induced Premature Senescence of Endothelial and Endothelial Progenitor Cells
Identifieur interne : 000A94 ( Main/Exploration ); précédent : 000A93; suivant : 000A95Stress-Induced Premature Senescence of Endothelial and Endothelial Progenitor Cells
Auteurs : M. S. Goligorsky [États-Unis] ; K. Hirschi [États-Unis]Source :
- Advances in pharmacology (San Diego, Calif.) [ 1054-3589 ] ; 2016.
Abstract
This brief overview of premature senescence of dysfunctional endothelial and endothelial progenitor cells provides information on endothelial cell differentiation and specialization, their ontogeny, and controversies related to endothelial stem and progenitor cells. Stressors responsible for the dysfunction of endothelial and endothelial progenitor cells, as well as cellular mechanisms and consequences of endothelial cell dysfunction are presented. Metabolic signatures of dysfunctional endothelial cells and senescence pathways are described. Emerging strategies to rejuvenate endothelial and endothelial progenitor cells conclude the review.
Url:
DOI: 10.1016/bs.apha.2016.04.007
PubMed: 27451101
PubMed Central: 5206791
Affiliations:
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